APC Anti-Human CD3 (Hit3a)
The Hit3a antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.
The Hit3a antibody is a widely used phenotypic marker for human T cells. In addition, binding/cross-linking of Hit3a antibody to CD3e can induce cell activation. The antibody has also been demonstrated to be cross-reactive with Chimpanzee CD3. Please choose the appropriate format for each application.
| Name | APC Anti-Human CD3 (Hit3a) |
|---|---|
| Cat. No. | 20-0039 |
| Alternative Names | Leu-4, T3 |
| Gene ID | 916 |
| Clone | Hit3a |
| Isotype | Mouse IgG2a, κ |
| Reactivity | Human |
| Cross Reactivity | Chimpanzee |
| Format | APC |
| Application | Flow Cytometry |
Description
The Hit3a antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.
The Hit3a antibody is a widely used phenotypic marker for human T cells. In addition, binding/cross-linking of Hit3a antibody to CD3e can induce cell activation. The antibody has also been demonstrated to be cross-reactive with Chimpanzee CD3. Please choose the appropriate format for each application.
| Name | APC Anti-Human CD3 (Hit3a) |
|---|---|
| Cat. No. | 20-0039 |
| Alternative Names | Leu-4, T3 |
| Gene ID | 916 |
| Clone | Hit3a |
| Isotype | Mouse IgG2a, κ |
| Reactivity | Human |
| Cross Reactivity | Chimpanzee |
| Format | APC |
| Application | Flow Cytometry |
