Purified Anti-Mouse CD8a (53-6.7)
The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.
The 53-6.7 antibody is widely used as a phenotypic marker for mouse CD8a expression on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.
| Name | Purified Anti-Mouse CD8a (53-6.7) |
|---|---|
| Cat. No. | 70-0081 |
| Alternative Names | CD8 alpha, Ly-2, Ly-35, Ly-B, Lyt-2 |
| Gene ID | 12525 |
| Clone | 53-6.7 |
| Isotype | Rat IgG2a, κ |
| Reactivity | Mouse |
| Format | Purified |
| Application | Flow Cytometry, IHCF, IHCP, IP |
Original: $62.00
-70%$62.00
$18.60
Description
The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.
The 53-6.7 antibody is widely used as a phenotypic marker for mouse CD8a expression on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.
| Name | Purified Anti-Mouse CD8a (53-6.7) |
|---|---|
| Cat. No. | 70-0081 |
| Alternative Names | CD8 alpha, Ly-2, Ly-35, Ly-B, Lyt-2 |
| Gene ID | 12525 |
| Clone | 53-6.7 |
| Isotype | Rat IgG2a, κ |
| Reactivity | Mouse |
| Format | Purified |
| Application | Flow Cytometry, IHCF, IHCP, IP |
