VAP-1 Monoclonal Antibody (TK8-14), eBioscience

PRODUCT DETAILS

Host: Mouse

Isotype: IgG2a

Clonality: Monoclonal

Clone: TK8-14

Reactivity: Hu

Application: Flow Cytometry

Tested Dilution: Assay-Dependent

Concentration: 1 mg/mL

Storage: -20°C

Formulation: PBS with no preservative; pH 7.2-7.4

Purification: Affinity chromatography

Data Sheet: TDS

Specific Information

Description: VAP-1 (TK8-14) is a mouse monoclonal antibody raised against affinity purifiedVAP-1 from tonsil stroma of human origin.

Lymphocyte binding to vascular endothelium is a prerequisite for the move-ment of immune cells from the blood into lymphoid tissues and into sites ofinflammation. Under inflammatory conditions, cell surface expression ofVAP-1 (vascular adhesion protein-1) which is an endothelial sialoglycoprotein,is induced. VAP-1 is a type II transmembrane protein of 84.6 kDa with a singletransmembrane domain and N and O-glycosylation sites in the extracellulardomain. In vivo, VAP-1 exists predominantly as a 180 kDa homodimer andfunctions both as an enzyme (monoamine oxidase) and an adhesion moleculefor lymphocytes.

Applications Tested: ELISA, Flow Cytometry, Immunofluorescence, Western Blotting.

 

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.